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Genome Biol. 2013 Nov 21;14(11):138. doi: 10.1186/gb4139.

Fixated on fixation: using ChIP to interrogate the dynamics of chromatin interactions.

Abstract

A new study exploits the time-dependence of formaldehyde cross-linking in the commonly used chromatin immunoprecipitation (ChIP) assay to infer the on and off rates for site-specific chromatin interactions.

PMID:
24257511
[PubMed - in process]
PMCID:
PMC4054896
Free PMC Article

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