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Reprod Toxicol. 2014 Jan;43:56-66. doi: 10.1016/j.reprotox.2013.11.001. Epub 2013 Nov 17.

Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats.

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  • 1Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil.
  • 2Departament of Pathology, School of Medicine - UNESP, Botucatu, SP 18618-970, Brazil.
  • 3Faculty of Dentistry, University of Sao Paulo - FORP/USP, Ribeirão Preto, SP 14040-904, Brazil.
  • 4Institute of Biology, University of Campinas - UNICAMP, Campinas, SP 13083-862, Brazil.
  • 5Department of Morphology, Institute of Biosciences, Sao Paulo State University - UNESP, Botucatu, SP 18618-970, Brazil. Electronic address:


Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 μg/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate.

Copyright © 2013 Elsevier Inc. All rights reserved.


Bisphenol A; Chemoprevention; Indole-3-carbinol; Inflammation; Prostate; Reproductive toxicology

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