Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Virol. 2014 Jan;59(1):63-6. doi: 10.1016/j.jcv.2013.10.027. Epub 2013 Nov 1.

Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.

Author information

  • 1NATO Role 3 Multi-National Medical Unit, Kandahar Airfield, Afghanistan; Division of Infectious Diseases, Department of Internal Medicine, Naval Medical Center San Diego, San Diego, CA, USA; Department of Pulmonary and Critical Care Medicine, Naval Medical Center San Diego, San Diego, CA, USA. Electronic address: ryan.maves@med.navy.mil.
  • 2NATO Role 3 Multi-National Medical Unit, Kandahar Airfield, Afghanistan; Department of Pulmonary and Critical Care Medicine, Naval Medical Center San Diego, San Diego, CA, USA.
  • 382nd Airborne Division, Fort Bragg, NC, USA.
  • 482nd Airborne Division, Fort Bragg, NC, USA; Military Malaria Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • 582nd Airborne Division, Fort Bragg, NC, USA; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
  • 6NATO Role 3 Multi-National Medical Unit, Kandahar Airfield, Afghanistan; Naval Medical Research Center, Silver Spring, Maryland, USA.
  • 7Applied Technology Center, United States Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, OH, USA.
  • 8NATO Role 3 Multi-National Medical Unit, Kandahar Airfield, Afghanistan; Applied Technology Center, United States Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, OH, USA.

Abstract

Varicella-zoster virus (VZV) infections have declined in many industrialized countries due to vaccination with the attenuated Oka strain virus. Rare cases of severe, disseminated vaccine-strain VZV infection have occurred in the immunocompromised, although rarely in HIV-infected persons. We describe a man with previously-undiagnosed human immunodeficiency virus (HIV) infection who received VZV vaccination and subsequently presented to a combat hospital in Afghanistan with disseminated varicella, respiratory failure, and sepsis. The patient recovered with ventilator and hemodynamic support, intravenous acyclovir, and empiric antibiotic therapy. DNA sequencing detected Oka strain virus from patient blood specimens. Although safe in most populations, the VZV vaccine may cause life-threatening disease in immunocompromised patients. Improved detection of HIV infection may be useful in preventing such cases.

Published by Elsevier B.V.

KEYWORDS:

AIDS; HIV-1; Operation Enduring Freedom; Varicella; Varicella vaccine

PMID:
24257110
[PubMed - in process]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk