Format

Send to:

Choose Destination
See comment in PubMed Commons below
Endoscopy. 2014 Mar;46(3):219-24. doi: 10.1055/s-0033-1358800. Epub 2013 Nov 19.

Prevalence of serrated polyps and association with synchronous advanced neoplasia in screening colonoscopy.

Author information

  • 1Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
  • 2Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • 3Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands.
  • 4Department of Pathology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • 5Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands.

Abstract

BACKGROUND AND STUDY AIMS:

Serrated polyps of the large intestine comprise a heterogeneous group of lesions with distinct histological and malignant features. The aim of the study was to estimate the prevalence of serrated polyp subtypes in a cohort of individuals undergoing screening colonoscopy, and to identify associations between the detection of serrated polyp subtypes and advanced neoplasia.

PATIENTS AND METHODS:

Data on serrated polyps, adenomas, and cancers were collected from participants of a randomized screening trial that compared colonoscopy with computed tomography colonography. Only data from participants in the colonoscopy arm were used. Logistic regression analyses were performed to identify associations between patients' age, sex, and prevalence of the different types of serrated polyps and to identify associations between the detection of these polyps and advanced neoplasia (defined as an adenoma ≥ 10 mm, villous component, high grade dysplasia or colorectal cancer).

RESULTS:

A total of 1426 screen-naïve individuals (51 % male) with a median age of 60 years (IQR 55 - 65) were included. The prevalence of hyperplastic polyps, sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adenomas (TSAs) was 23.8 %, 4.8 %, and 0.1 %, respectively. SSA/Ps comprised 7.3 % of all polyps. No differences based on age or sex were observed in the prevalence of SSA/Ps. Proximal and large (≥ 10 mm) hyperplastic polyps, as well as proximal and large (≥ 10 mm) SSA/Ps, were associated with synchronous advanced neoplasia.

CONCLUSIONS:

Serrated polyps, including SSA/Ps, were frequently encountered in routine screening colonoscopies. Large and proximal hyperplastic polyps, as well large and proximal SSA/Ps, were associated with advanced neoplasia.

© Georg Thieme Verlag KG Stuttgart · New York.

Comment in

PMID:
24254386
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Georg Thieme Verlag Stuttgart, New York
    Loading ...
    Write to the Help Desk