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Toxicol Appl Pharmacol. 2014 Jan 1;274(1):117-23. doi: 10.1016/j.taap.2013.11.004. Epub 2013 Nov 15.

Urinary arsenic metabolism in a Western Chinese population exposed to high-dose inorganic arsenic in drinking water: influence of ethnicity and genetic polymorphisms.

Author information

  • 1Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health (23618104), Harbin 150081, China.
  • 2Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
  • 3Department of Health Statistics, Harbin Medical University, Harbin 150081, China.
  • 4Dongcheng District Center for Disease Control and Prevention, Beijing 100009, China.
  • 5Gansu Center for Disease Control and Prevention, 730020, China.
  • 6Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health (23618104), Harbin 150081, China. Electronic address: hrbmusdj@163.com.

Abstract

To investigate the differences in urinary arsenic metabolism patterns of individuals exposed to a high concentration of inorganic arsenic (iAs) in drinking water, an epidemiological investigation was conducted with 155 individuals living in a village where the arsenic concentration in the drinking water was 969μg/L. Blood and urine samples were collected from 66 individuals including 51 cases with skin lesions and 15 controls without skin lesions. The results showed that monomethylated arsenic (MMA), the percentage of MMA (%MMA) and the ratio of MMA to iAs (MMA/iAs) were significantly increased in patients with skin lesions as compared to controls, while dimethylated arsenic (DMA), the percentage of DMA (%DMA) and the ratio of DMA to MMA (DMA/MMA) were significantly reduced. The percent DMA of individuals with the Ala/Asp genotype of glutathione S-transferase omega 1 (GSTO1) was significantly lower than those with Ala/Ala. The percent MMA of individuals with the A2B/A2B genotype of arsenic (+3 oxidation state) methyltransferase (AS3MT) was significantly lower than those with AB/A2B. The iAs and total arsenic (tAs) content in the urine of a Tibetan population were significantly higher than that of Han and Hui ethnicities, whereas MMA/iAs was significantly lower than that of Han and Hui ethnicities. Our results showed that when exposed to the same arsenic environment, different individuals exhibited different urinary arsenic metabolism patterns. Gender and ethnicity affect these differences and above polymorphisms may be effectors too.

Copyright © 2013. Published by Elsevier Inc.

KEYWORDS:

AS3MT; Arsenic; GSTO1; GSTO2; Genetic polymorphism; Methylation metabolism

PMID:
24239724
[PubMed - indexed for MEDLINE]
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