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Trends Pharmacol Sci. 2013 Dec;34(12):648-55. doi: 10.1016/j.tips.2013.10.005. Epub 2013 Nov 12.

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

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  • 1Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.

Abstract

A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling enzymes with their substrates. Great strides have been made in elucidating the role of these macromolecular signaling complexes as new binding partners and novel AKAPs are continually being uncovered. The mechanics and dynamics of these multi-enzyme assemblies suggest that AKAP complexes are viable targets for therapeutic intervention. This review will highlight recent advances in AKAP research focusing on local signaling events that are perturbed in disease.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

AKAP; Ca(2+); disease; interfering peptide; protein kinase; protein phosphatase; signal transduction

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