Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Forensic Leg Med. 2013 Nov;20(8):1024-7. doi: 10.1016/j.jflm.2013.09.019. Epub 2013 Oct 2.

Lack of impairment due to confirmed codeine use prior to a motor vehicle accident: role of pharmacogenomics.

Author information

  • 1Department of Laboratory Medicine, University of California, San Francisco, CA, USA. Electronic address: wualan@labmed2.ucsf.edu.

Abstract

BACKGROUND:

We examined forensic serum toxicology and pharmacogenomics data from a woman on codeine shortly before she caused a motor vehicle accident.

METHODS:

A woman driving erratically collided with a parked car of a highway seriously injuring 2 men working to repair the parked vehicle. The woman tested positive for codeine, acetaminophen and barbital. She had been taking these medications for 20 years due to migraine headache. Serum toxicology and genotype analysis for cytochrome P450, UDP glucuronosyltransferase, and other metabolizing enzymes were measured.

RESULTS:

The woman was tried and convicted of driving under the influence resulting in bodily harm and was sentenced to 6 years. Toxicology results on peripheral blood showed a total and free codeine of 840 and 348 μg/L, respectively, and total morphine of 20 μg/L (17, 3, and 0 μg/L for morphine-3-glucuronide, morphine-6-glucuronide, and free morphine, respectively). She was heterozygous for CYP 2D6 *2/*4 (extensive/poor metabolism) and heterozygous for UGT 2B7 *1/*2 (extensive/ultra-rapid metabolism). The woman was also taking fluoxetine and bupropion which are strong inhibitors of CYP 2D6.

CONCLUSIONS:

Based on her genotype and phenotype and reports by the arresting officer, we suggest that the subject in question was not intoxicated by opiates at the time of her motor vehicle accident and may have been falsely incarcerated.

Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

KEYWORDS:

Codeine; Cytochrome P450; Glucuronide; Morphine; UDP glucuronosyltransferase; UDP glucuronosyltransferase pharmacogenomics

PMID:
24237812
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk