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J Org Chem. 2013 Dec 20;78(24):12629-36. doi: 10.1021/jo402248d. Epub 2013 Nov 19.

One-pot synthesis of 7,9-dialkylpurin-8-one analogues: broad substrate scope.

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  • 1School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University , Xinxiang 453007, Henan, China.


The one-pot and direct synthesis of 7,9-dialkylpurin-8-one analogues with broad substrate scope has been developed. This copper-catalyzed C-H oxidation reaction could avoid multistep synthesis of quaternary ammonium salts and expand the scope of halogenated alkanes. Moreover, benzimidazole derivatives are also applicable in the catalytic system.

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