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World J Pediatr. 2013 Nov;9(4):342-5. doi: 10.1007/s12519-013-0442-0. Epub 2013 Nov 14.

Efficacy and safety of serial injections of botulinum toxin A in children with spastic cerebral palsy.

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  • 1Department of Pediatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China, yajienet@yahoo.com.cn.



Botulinum toxin A (BTX-A) has been successfully used as a treatment for children with spastic cerebral palsy; however, the effect of BTX-A on reducing spasticity only lasts a few months, thus serial injections are required. The present study was to evaluate the efficacy and safety of serial injections of BTX-A in children with spastic cerebral palsy.


Fifty-two pediatric patients with spastic cerebral palsy, 2-12 years of age (mean age, 4.79 ± 2.70), were retrospectively analyzed. Muscle tone was assessed with the Modified Ashworth Scale, and gait was assessed with the Physician Rating Scale. Assessments were undertaken at baseline, 3 months, and 6 months after serial injections of BTX-A.


The beneficial effects of BTX-A occurred 1 week after the injection, whereas the adverse side-effects appeared within 1 week and lasted <2 weeks. BTX-A significantly improved muscle tone and gait 3 and 6 months after its serial injections compared to baseline (P <0.05).


Serial injections of BTX-A are effective and safe for children with spastic cerebral palsy. The sideeffects of serial injections of BTX-A are mild and selflimited.

[PubMed - indexed for MEDLINE]
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