Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Otol Neurotol. 2013 Dec;34(9):1660-5. doi: 10.1097/MAO.0b013e3182a036e4.

Enlarged cochlear aqueducts: a potential route for CSF gushers in patients with enlarged vestibular aqueducts.

Author information

  • 1*Department of Otorhinolaryngology, Yonsei University, College of Medicine, Seoul; †Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu; and ‡Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea.



We investigated whether the size of the cochlear aqueduct (CA) is increased in patients with enlarged vestibular aqueducts (EVAs) compared with individuals with normal inner ear anatomy. Furthermore, we assessed whether the size of the CA is related to the cerebrospinal fluid (CSF) gusher during cochlear implantation (CI) surgery.


Retrospective study.


Tertiary referral center.


The medical records for 35 patients with a biallelic SLC26A4 mutation were reviewed. All of the patients were confirmed to have EVA by temporal bone computed tomography (TBCT) and biallelic SLC26A4 mutation by genetic analysis. Thirty-six age- and sex-matched patients without a mutation in the SLC26A4 gene were selected as comparison group.


The diameters of the CA and vestibular aqueduct (VA) were measured, and the type of CA was evaluated using TBCT.


The CA was larger in patients with EVA (2.39 ± 0.99 mm) as compared with controls (1.76 ± 0.87 mm; p < 0.001). The types that could be most easily visualized from the subarachnoid space to the cochlea were more common in patients with EVA. Furthermore, mean CA size was significantly larger in EVA patients with CSF gushers (3.65 ± 1.12 mm) as compared with those without CSF gushers (2.03 ± 0.66 mm; p < 0.001).


The CA is a potential pathway for CSF gushers between the subarachnoid space and the inner ear. Therefore, we suggest that evaluation of the CA by TBCT may be helpful in predicting intraoperative CSF gushers in patients with EVA.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk