Abstract
A new synthetic stable analog of prostacyclin (ZK 36 374, Iloprost) has been shown to inhibit gastric lesions due to restraint-cold stress in rats in a dose-dependent manner. Therefore substitution of the decreased prostacyclin in the gastric mucosa may play an important role in the prevention or treatment of gastric ulcers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cold Temperature
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Dose-Response Relationship, Drug
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Epoprostenol / administration & dosage
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Epoprostenol / therapeutic use*
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Female
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Gastric Mucosa / drug effects
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Iloprost
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Injections, Intraperitoneal
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Male
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Rats
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Rats, Inbred Strains
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Stomach Ulcer / drug therapy
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Stomach Ulcer / prevention & control*