A novel cyclin, cyclin Y, is one of the most highly conserved members of the cyclin superfamily, which is famous for their important roles in regulating the cell cycle and transcription. Recently, it was found that cyclin Y was up-regulated in many cancers. Cyclin Y may play a crucial role in tumor progression. The function and molecular mechanism of cyclin Y protein will be discussed in this paper.
近年来，陆续有一些新的周期素蛋白被发现，细胞周期素Y（cyclin Y, CCNY）即为其中之一。现有的研究表明cyclinY高度保守，在调节细胞周期及转录过程中发挥重要作用，而且cyclin Y 在多种肿瘤组织中高表达，在肿瘤增殖调控中可能发挥重要的功能。现就cyclin Y 的研究进展及其与肿瘤的关系做一综述。