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Zhong Yao Cai. 2013 May;36(5):747-51.

[Study on chemical components of Aconitum flavum and their inflammatory and analgesic effects].

[Article in Chinese]

Author information

  • 1School of Pharmaceutical Sciences, Ningxia Medical University, Yinchuan 750004, China. fuxueyan1215@yahoo.com.cn

Abstract

OBJECTIVE:

To study the chemical compositions of active site of Aconitum flavum and their pharmacological effects on anti-inflammatory andantalgic.

METHODS:

Xylene-induced mice ear swollen and egg white-induce toe swollen test were used to assess the anti-inflammatory effect of Aconitum flavum. Acetic acid-induce mice writhing and hot-plate test were used to assess the antalgic effect of Aconitum flavum. Silica gel, ODS and Sephadex LH-20 techniques were employed for isolation and purification the constituents of Aconitum flavum. The chemical compounds were identified by 1H-NMR, 13C-NMR, DEPT, HMBC, HMQC and COSY.

RESULTS:

When compared with model group, there was significant difference in 30% alcohol active extract group (P < 0.05) in xylene-induce mice ear-swollen test. In the experiment of egg white-induce toe swollen test, 30% alcohol active extract group had great significant difference when compared with the model group (P < 0.01). In acetic acid writhing test, 30% alcohol active extract group had significant analgesic action when compared with model group. In hot plate test, when compared with model group, the analgesic effect of 30% alcohol active extract group (P < 0.05) at 30 and 45 minutes after administration was significanty increased. Fourteen compounds were isolated from the active extract,while seven compounds were identified as: sucrose (I), linarin (Ii), beta-sitosterol (III), beta-daucosterol (IV), beta-sitosterol-3, 5, 6-triol (VII), aconitine (V ) and hypaconitine (IV).

CONCLUSION:

30% alcohol active extract of Aconitum flavum has anti-inflammatory and antalgic effects. Compounds I, II, IV, VI and VII are isolated for the first time.

PMID:
24218966
[PubMed - indexed for MEDLINE]
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