Brain Res. 1986 Mar 5;367(1-2):346-50.

Calcitonin and calcitonin gene-related peptide enhance calcium-dependent potentials.

Nohmi M, Shinnick-Gallagher P, Gean PW, Gallagher JP, Cooper CW.

Abstract

Recent data suggests that calcitonin (CT) and/or calcitonin gene-related peptide (CGRP) may be potential transmitters or modulators in the nervous system. The present study analyzed the effect of CT and CGRP on the neuronal membranes of cat parasympathetic ganglia of the urinary bladder. The related peptides prolonged the duration of the afterhyperpolarization of the action potential but had no effect on resting potential or input resistance. CT and CGRP enhanced the duration of a calcium spike recorded in the presence of agents blocking Na and K channels while under similar conditions forskolin, an activator of adenylate cyclase, did not affect the calcium spike. These data suggest that the neural mechanism of action of CT and CGRP is to prolong a calcium conductance and that these effects are not mediated through cyclic AMP.

PMID:: 2421835; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Elsevier Science

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Actions of calcitonin gene-related peptide on a population of submandibular ganglion cells. [Bull Tokyo Dent Coll. 1998]
Actions of calcitonin gene-related peptide on a population of submandibular ganglion cells.
Ono H, Endoh T, Suzuki T. Bull Tokyo Dent Coll. 1998 Nov; 39(4):251-62.
Activators of adenylate cyclase and cyclic AMP prolong calcium-dependent action potentials of mouse sensory neurons in culture by reducing a voltage-dependent potassium conductance. [J Neurosci. 1987]
Activators of adenylate cyclase and cyclic AMP prolong calcium-dependent action potentials of mouse sensory neurons in culture by reducing a voltage-dependent potassium conductance.
Grega DS, Macdonald RL. J Neurosci. 1987 Mar; 7(3):700-7.
Fast hyperpolarization following an excitatory postsynaptic potential in cat bladder parasympathetic neurons. [Neuroscience. 1989]
Fast hyperpolarization following an excitatory postsynaptic potential in cat bladder parasympathetic neurons.
Kumamoto E, Nohmi M, Shinnick-Gallagher P. Neuroscience. 1989; 30(3):671-81.
Review Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. [Crit Rev Neurobiol. 1997]
Review Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.
Wimalawansa SJ. Crit Rev Neurobiol. 1997; 11(2-3):167-239.
Review Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone. [J Musculoskelet Neuronal Inter...]
Review Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone.
Lerner UH. J Musculoskelet Neuronal Interact. 2006 Jan-Mar; 6(1):87-95.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Calcitonin and calcitonin gene-related peptide enhance calcium-dependent potenti...
Calcitonin and calcitonin gene-related peptide enhance calcium-dependent potentials.
Brain Res. 1986 Mar 5 ;367(1-2):346-50.

PubMed
A rare type of low birthweight dwarfism: the Dubowitz syndrome.
A rare type of low birthweight dwarfism: the Dubowitz syndrome.
Z Kinderheilkd. 1975 Nov 13 ;120(4):283-92.

PubMed
Molecular identity of a major antigen of Schistosoma mansoni which cross-reacts ...
Molecular identity of a major antigen of Schistosoma mansoni which cross-reacts with Trichinella spiralis and Fasciola hepatica.
Parasitology. 1986 Feb ;92 ( Pt 1):133-51.

PubMed
International Commission for Protection Against Environmental Mutagens and Carci...
International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Meeting Report No. 2. Approaches to determining mutation rates in human DNA.
Mutat Res. 1986 May ;167(3):215-32.

PubMed
Traumatized permanent teeth in children aged 7-15 years.
Traumatized permanent teeth in children aged 7-15 years.
Sven Tandlak Tidskr. 1975 ;68(5):157-69.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Calcitonin and calcitonin gene-related peptide enhance calcium-dependent potentials.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information