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Tumour Biol. 2014 Mar;35(3):2675-9. doi: 10.1007/s13277-013-1352-4. Epub 2013 Nov 12.

Association between IL-4 -589C>T polymorphism and colorectal cancer risk.

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  • 1Proctology Department, Liaocheng People's Hospital, Liaocheng City, 252000, Shandong Province, China, li_qiangd@hotmail.com.


In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.

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