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Ophthalmologica. 2014;231(1):51-7. doi: 10.1159/000355093. Epub 2013 Nov 9.

Exclusion of influences of ARMS2 polymorphisms on the central visual field in retinitis pigmentosa.

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  • 1Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Abstract

PURPOSE:

To investigate the effects of polymorphisms of the age-related maculopathy susceptibility 2 (ARMS2) gene on the central visual field defects in retinitis pigmentosa (RP).

SUBJECTS AND METHODS:

The visual field was evaluated using the 10-2 Swedish Interactive Threshold Algorithm Fast Program and mean deviation (MD) slope, and regression coefficients of average sensitivity of the central 4 points (Cent4) were compared between each genetic subgroup.

RESULTS:

The MD slope (right/left) was as follows: GG, -1.37 ± 2.18/ -0.89 ± 1.15; GT, -0.56 ± 1.40/-0.77 ± 1.04; TT, -0.75 ± 0.64/ -0.38 ± 0.92 dB/year. The Cent4 was as follows: GG, -1.34 ± 2.37/-1.60 ± 3.21; GT, -1.15 ± 2.08/1.07 ± 1.80; TT, -1.20 ± 0.91/-0.65 ± 1.37 dB/year. No significant differences in the degree of progression were observed when comparing groups.

CONCLUSIONS:

These data suggest that polymorphisms of the ARMS2 do not modify the progression of the central field of vision in RP patients.

© 2013 S. Karger AG, Basel.

PMID:
24217333
[PubMed - indexed for MEDLINE]
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