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Gastrointest Endosc Clin N Am. 2014 Jan;24(1):83-107. doi: 10.1016/j.giec.2013.08.010.

Techniques for endoscopic ultrasound-guided fine-needle biopsy.

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  • 1Digestive Endoscopy Unit, Catholic University, Largo A. Gemelli, 8, Rome 00168, Italy; Department of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia.


Although endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the method of choice to obtain samples to reach definitive diagnosis of lesions of the gastrointestinal tract and of adjacent organs, it cannot fully characterize certain neoplasms. The lack of cytology expertise has hindered the dissemination of EUS, limiting its widespread use. The obtainment of a tissue specimen through EUS fine-needle biopsy (EUS-FNB) may overcome the limitations of EUS-FNA. EUS-FNB is expected to move the practice of EUS from cytology to histology, expanding the use of EUS and facilitating targeted therapies and monitoring of treatment response in a more biologically driven manner.

Copyright © 2014 Elsevier Inc. All rights reserved.


Core biopsy; Endoscopic ultrasonography; Fine-needle aspiration; Fine-needle biopsy; Histology; Tissue acquisition

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