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Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13606-10. doi: 10.1002/anie.201307090. Epub 2013 Nov 8.

An efficient palladium-catalyzed C-H alkoxylation of unactivated methylene and methyl groups with cyclic hypervalent iodine (i(3+) ) oxidants.

Author information

  • 1MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084 (China).

Erratum in

  • Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2021.


All the hype: The title reaction has been developed for the facile synthesis of a variety of complex alkyl ethers. Cyclic hypervalent iodine (I(3+) ) reagents serve as oxidants for this unique CH alkoxylation reaction. The reaction demonstrates excellent reactivity, good functional-group tolerance, and high yields. Q=8-aminoquinoline-derived auxiliary.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


CH activation; hypervalent compounds; iodine; oxidation; palladium

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