Large for gestational age and long-term cognitive function

Am J Obstet Gynecol. 2014 Apr;210(4):343.e1-343.e4. doi: 10.1016/j.ajog.2013.11.003. Epub 2013 Nov 7.

Abstract

Objective: As we have previously published, small-for-gestational-age (<3% birthweight [BW]) newborns exhibit catch-up cognitive functioning by age 2 years. Our objective was to compare cognitive functioning in children born with ≥90% vs 5-89% BW for gestational age (WGA) between 9 months and kindergarten.

Study design: Nonanomalous singletons from Early Childhood Longitudinal Study-Birth Cohort with BW ≥90% vs 5-89% were compared. Cognitive and academic functioning was measured at 4 time points: 9 months, and 2, 3.5, and 5.5 years. Associations between WGA and cognitive functioning at each time point was examined using confounder-adjusted general linear model-based methods.

Results: Of 2930 cases, 271 (9.2%) were ≥90% WGA. In terms of cognitive performance, children ≥90% WGA were not statistically different (P = .068) from normal WGA at any time point, nor did they change at different rates across early childhood.

Conclusion: There is no difference in cognitive function in children with BW 5-89% vs ≥90% for GA.

Keywords: cognitive functioning; large-for-gestational-age infants.

MeSH terms

  • Birth Weight*
  • Case-Control Studies
  • Child Development*
  • Child, Preschool
  • Cognition*
  • Female
  • Fetal Macrosomia / epidemiology
  • Humans
  • Infant, Newborn
  • Intelligence Tests
  • Longitudinal Studies
  • Male
  • Pregnancy
  • Prospective Studies