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Trends Cogn Sci. 2013 Dec;17(12):596-9. doi: 10.1016/j.tics.2013.10.005. Epub 2013 Nov 6.

Light microscopy mapping of connections in the intact brain.

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  • 1Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.


Mapping of neural connectivity across the mammalian brain is a daunting and exciting prospect. Current approaches can be divided into three classes: macroscale, focusing on coarse inter-regional connectivity; mesoscale, involving a finer focus on neurons and projections; and microscale, reconstructing full details of all synaptic contacts. It remains to be determined how to bridge the datasets or insights from the different levels of study. Here we review recent light-microscopy-based approaches that may help in integration across scales.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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