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Biophys J. 2013 Nov 5;105(9):L19-22. doi: 10.1016/j.bpj.2013.09.023.

Kinetics and energetics of biomolecular folding and binding.

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  • 1Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California.


The ability of biomolecules to fold and to bind to other molecules is fundamental to virtually every living process. Advanced experimental techniques can now reveal how single biomolecules fold or bind against mechanical force, with the force serving as both the regulator and the probe of folding and binding transitions. Here, we present analytical expressions suitable for fitting the major experimental outputs from such experiments to enable their analysis and interpretation. The fit yields the key determinants of the folding and binding processes: the intrinsic on-rate and the location and height of the activation barrier.

Copyright © 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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