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Cell. 2013 Nov 7;155(4):744-9. doi: 10.1016/j.cell.2013.10.003.

The frustrated gene: origins of eukaryotic gene expression.

Author information

  • Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: hitenmadhani@gmail.com.

Abstract

Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
24209615
[PubMed - indexed for MEDLINE]
PMCID:
PMC4163148
[Available on 2014/11/7]
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