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Nihon Rinsho. 2013 Sep;71(9):1655-60.

[Statin therapy for atherogenic hypertriglyceridemia].

[Article in Japanese]

Author information

  • Division of Cardiology, Department of Medicine, Showa University School of Medicine.

Abstract

LDL-cholesterol lowering by statins substantially reduces morbidity and mortality of coronary heart disease (CHD) and ischemic stroke. Statins are the most potent agents for lowering circulating LDL particles. Accumulation of triglyceride-rich remnant lipoproteins in both fasting and postprandial state is strongly associated with the formation of highly atherogenic small dense LDL. Although dose-dependent reductions in levels of atherogenic lipids are observed with all statin, strong statins such as rosuvastatin, atorvastatin, and pitavastatin, can reduce the triglyceride and small dense LDL greater than other statins. Statin is one of the first-line drugs for management of hypertriglyceridemia with elevated LDL-cholesterol and/or non HDL-cholesterol. Aggressive LDL-cholesterol lowering may be required for the management of high-risk CHD patients with both high LDL-cholesterol and triglyceride.

PMID:
24205730
[PubMed - indexed for MEDLINE]
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