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PLoS One. 2013 Oct 21;8(10):e77901. doi: 10.1371/journal.pone.0077901. eCollection 2013.

Can K-ras gene mutation be utilized as prognostic biomarker for colorectal cancer patients receiving chemotherapy? A meta-analysis and systematic review.

Author information

  • 1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China ; Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Abstract

INTRODUCTION:

K-ras gene mutations were common in colorectal patients, but their relationship with prognosis was unclear.

OBJECTIVE:

Verify prognostic differences between patient with and without mutant K-ras genes by reviewing the published evidence.

METHOD:

Systematic reviews and data bases were searched for cohort/case-control studies of prognosis of colorectal cancer patients with detected K-ras mutations versus those without mutant K-ras genes, both of whom received chemotherapy. Number of patients, regimens of chemotherapy, and short-term or long-term survival rate (disease-free or overall) were extracted. Quality of studies was also evaluated.

PRINCIPAL FINDINGS:

7 studies of comparisons with a control group were identified. No association between K-ras gene status with neither short-term disease free-survival (OR=1.01, 95% CI, 0.73-1.38, P=0.97) nor overall survival (OR=1.06, 95% CI, 0.82-1.36, P=0.66) in CRC patients who received chemotherapy was indicated. Comparison of long-term survival between two groups also indicated no significant difference after heterogeneity was eliminated (OR=1.09, 95% CI, 0.85-1.40, P=0.49).

CONCLUSIONS:

K-ras gene mutations may not be a prognostic index for colorectal cancer patients who received chemotherapy.

PMID:
24205021
[PubMed - indexed for MEDLINE]
PMCID:
PMC3804628
Free PMC Article
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