Format

Send to

Choose Destination
See comment in PubMed Commons below
J Allergy Clin Immunol. 2014 Mar;133(3):713-22.e4. doi: 10.1016/j.jaci.2013.09.023. Epub 2013 Nov 4.

Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population.

Author information

  • 1Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
  • 2Department of Biostatistics, Harvard School of Public Health, Boston, Mass; Department of Environmental Health, Harvard School of Public Health, Boston, Mass.
  • 3Department of Environmental Health, Harvard School of Public Health, Boston, Mass.
  • 4Department of Environmental Health, Harvard School of Public Health, Boston, Mass; Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel.
  • 5Department of Environmental Health, Harvard School of Public Health, Boston, Mass; Department of Epidemiology, Harvard School of Public Health, Boston, Mass.
  • 6Department of Psychology, Carnegie Mellon University, Pittsburgh, Pa.
  • 7Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: rosalind.wright@mssm.edu.

Abstract

BACKGROUND:

Prenatal exposures to stress and physical toxins influence children's respiratory health, although few studies consider these factors together.

OBJECTIVES:

We sought to concurrently examine the effects of prenatal community-level psychosocial (exposure to community violence [ECV]) and physical (air pollution) stressors on repeated wheeze in 708 urban children followed to age 2 years.

METHODS:

Multi-item ECV reported by mothers in pregnancy was summarized into a continuous score by using Rasch modeling. Prenatal black carbon exposure was estimated by using land-use regression (LUR) modeling; particulate matter with a diameter of less than 2.5 μm (PM2.5) was estimated by using LUR modeling incorporating satellite data. Mothers reported child's wheeze every 3 months. The effects of ECV and air pollutants on repeated wheeze (≥ 2 episodes) were examined by using logistic regression. Interactions between ECV and pollutants were examined.

RESULTS:

Mothers were primarily black (29%) and Hispanic (55%), with lower education (62% with ≤ 12 years); 87 (12%) children wheezed repeatedly. In models examining concurrent exposures, ECV (odds ratio [OR], 1.95; 95% CI, 1.13-3.36; highest vs lowest tertile) and black carbon (OR, 1.84; 95% CI, 1.08-3.12; median or greater vs less than median) were independently associated with wheeze adjusting for sex, birth season, maternal atopy, education, race, and cockroach antigen. Associations were similar for PM2.5 (adjusted OR, 2.02; 95% CI, 1.20-3.40). An interaction between ECV with air pollution levels was suggested.

CONCLUSIONS:

These findings suggest that both prenatal community violence and air pollution can contribute to respiratory health in these urban children. Moreover, place-based psychosocial stressors might affect host resistance such that physical pollutants can have adverse effects, even at relatively lower levels.

Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

KEYWORDS:

Community violence; particulate matter; prenatal exposure; prenatal stress; repeated wheeze; traffic air pollution

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk