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Nat Cell Biol. 2013 Nov;15(11):1263-5. doi: 10.1038/ncb2877.

Crosstalk between mTOR complexes.

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  • 1Centre for Biological Sciences, Life Sciences Building (B85), University of Southampton, Southampton SO17 1BJ, UK.

Abstract

The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

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PMID:
24189516
[PubMed - indexed for MEDLINE]
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