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World J Nephrol. 2012 Oct 6;1(5):123-6. doi: 10.5527/wjn.v1.i5.123.

Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old.

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  • 1Carlos Guido Musso, José Ricardo Jauregui, Ageing Biology Unit, Hospital Italiano of Buenos Aires, Gascón 450, Argentina.


RENAL PHYSIOLOGY IN THE HEALTHY OLDEST OLD HAS THE FOLLOWING CHARACTERISTICS, IN COMPARISON WITH THE RENAL PHYSIOLOGY IN THE YOUNG: a reduced creatinine clearance, tubular pattern of creatinine back-filtration, preserved proximal tubule sodium reabsorption and uric acid secretion, reduced sodium reabsorption in the thick ascending loop of Henle, reduced free water clearance, increased urea excretion, presence of medulla hypotonicity, reduced urinary dilution and concentration capabilities, and finally a reduced collecting tubules response to furosemide which expresses a reduced potassium excretion in this segment due to a sort of aldosterone resistance. All physiological changes of the aged kidney are the same in both genders.


Ageing; Creatinine; Electrolytes; Oldest old; Renal; Urea; Uric acid; Water

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