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Eur Rev Med Pharmacol Sci. 2013 Oct;17(20):2766-72.

Effect of methylprednisolone and edaravone administration on spinal cord injury.

Author information

  • 1Department of Osteology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province, People's Republic of China. panzhangmd@hotmail.com.

Abstract

BACKGROUND:

Spinal cord injury (SCI) is one of the most devastating traumatic conditions that primarily affects young males with an annual incidence of 15-40 cases per million.

AIM:

To explore the superior neuroprotective effect of edaravone (ED) on spinal cord injury during maintenance therapy compared with methylprednisolone (MP).

MATERIALS AND METHODS:

Sprague-Dawley rat model of spinal cord injury was established by modified Allen's method. Total 114 rats were divided into two groups and then six subgroups individually: A1 (control group, normal saline injection within 8 h), B1 (MP group, MP injection within 8 h), C1(ED group, ED injection within 8 h), A2 (control group, normal saline injection after 8 h), B1 (MP group, MP injection after 8 h), C1 (ED group, ED injection after 8 h). Further, we investigated the changes of histopathology, caspase-3 and Bcl-xL positive cell.

RESULTS:

Haemorrhage, swelling, hyperaemia, gliocytes hyperplasia, inflammatory cells infiltration, vacuolar denaturation, and nucleus concentration could be observed, especially in control group. Caspase-3 positive cell was significantly decreased in MP and ED group within 8 h administration, but caspase-3 positive cell was only significantly decreased in ED group after 8 h administration. And B-cell lymphoma extra large (Bcl-xL) was significantly increased in ED group than MP group no matter within 8 h or after 8 h administration.

CONCLUSIONS:

More attention should be paid on the time point of MP administration, and ED administration seem to be more effective for maintenance therapy.

PMID:
24174358
[PubMed - indexed for MEDLINE]
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