Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Immunol. 2014 Feb;57(2):216-9. doi: 10.1016/j.molimm.2013.10.002. Epub 2013 Oct 27.

Involvement of Fcα/μR (CD351) in autoantibody production.

Author information

  • 1Department of Immunology, Institute of Basic Medical Sciences, Faculty of Medicine, Tsukuba, Japan.

Abstract

Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Fas(lpr/lpr) (Fcamr(-/-)Fas(lpr/lpr)) mice. Fcamr(-/-)Fas(lpr/lpr) mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr(+/+)Fas(lpr/lpr) mice. Moreover, Fcamr(-/-)Fas(lpr/lpr) mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr(+/+)Fas(lpr/lpr) mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Autoantibody; Fc receptor; IgM

PMID:
24172225
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk