Abstract
We have examined for the first time the relationship between the expression of PAPP-A metalloproteinase and insulin-like growth factors (IGF-I, IGF-II, VEGF) and transcription factors (NF-kappaB, HIF-1) playing an important role in pathogenesis of cancer. We also demonstrated a positive association between the level of PAPP-A metalloproteinase and the level of growth (VEGF and IGF-I) and transcription factors (NF-kappaB p50, NF-kappaB p65, HIF-1alpha). The current findings suggest an important role of PAPP-A in regulation of bioavailability of IGF-I, VEGF, activated forms of NF-kappaB, and alpha-subunits of HIF-1 in endometrial tumors.
MeSH terms
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Endometrial Neoplasms / genetics*
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Endometrial Neoplasms / pathology
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism
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Insulin-Like Growth Factor II / genetics
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Insulin-Like Growth Factor II / metabolism
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Middle Aged
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NF-kappa B / genetics
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NF-kappa B / metabolism
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Neoplasm Staging
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Pregnancy-Associated Plasma Protein-A / genetics
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Pregnancy-Associated Plasma Protein-A / metabolism*
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Transcription Factors / biosynthesis
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
Substances
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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NF-kappa B
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Transcription Factors
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Insulin-Like Growth Factor I
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Insulin-Like Growth Factor II
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Pregnancy-Associated Plasma Protein-A
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PAPPA protein, human