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Curr Opin Immunol. 2013 Dec;25(6):670-5. doi: 10.1016/j.coi.2013.10.004. Epub 2013 Oct 26.

Dendritic cells in tolerance and autoimmune diabetes.

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  • 1Centre de Physiopathologie de Toulouse Purpan, Université Toulouse III Paul-Sabatier, Toulouse F-31300, France; INSERM, U1043, Toulouse F-31300, France; CNRS, UMR5282, Toulouse F-31300, France. Electronic address: sylvie.guerder@inserm.fr.

Abstract

Type 1 diabetes is a T cell mediated autoimmune disease where both central and peripheral mechanisms effect T cell tolerance induction. Dendritic cells (DCs) are key regulators of innate and adaptive immune responses. They significantly contribute to central and peripheral T cell tolerance and, following maturation, induce the activation and differentiation of naïve T cells into effector and memory cells. DCs are also major actors in inflammation. Given these multiple effects on immune responses, DCs are suspected to contribute to autoimmune diseases. In this review we discuss how some specific features of DC may contribute to type 1 diabetes.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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