Send to

Choose Destination
See comment in PubMed Commons below
Head Neck. 2014 Dec;36(12):1705-11. doi: 10.1002/hed.23523. Epub 2014 Feb 1.

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: a single institutional experience at a tertiary care center.

Author information

  • 1Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, Ohio.



The purpose of this study was to determine factors that impact recurrence and long-term survival of head and neck adenoid cystic carcinoma (ACC).


We conducted a retrospective review of 87 patients with head and neck ACC who were evaluated between 1992 and 2009. Staining for Ki-67, p53, α-estrogen receptor (αER), and progesterone receptor (PR) was performed.


Forty men (46%) and 47 women (54%) were included in this study. Median follow-up for patients was 98 months. Five-year recurrence-free and overall survival (OS) rates were 56% and 81%, respectively. Ki-67 and p53 expression was observed in 5 (6%) and 2 (2%) patients, respectively. αER and PR were all negative. The most important determinants of disease-free survival (DFS) were perineural invasion (PNI; p = .001) and female sex (p = .027). Disease site (major vs minor salivary gland) was the only predictor of worse OS on multivariate analysis.


Perineural invasion, female sex, and disease site were the most consistent predictors of poor outcome in head and neck ACC.

© 2014 Wiley Periodicals, Inc.


adenoid cystic carcinomas; disease-free survival; head and neck; overall survival; prognostic factors

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk