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Head Neck. 2014 Dec;36(12):1705-11. doi: 10.1002/hed.23523. Epub 2014 Feb 1.

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: a single institutional experience at a tertiary care center.

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  • 1Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Abstract

BACKGROUND:

The purpose of this study was to determine factors that impact recurrence and long-term survival of head and neck adenoid cystic carcinoma (ACC).

METHODS:

We conducted a retrospective review of 87 patients with head and neck ACC who were evaluated between 1992 and 2009. Staining for Ki-67, p53, α-estrogen receptor (αER), and progesterone receptor (PR) was performed.

RESULTS:

Forty men (46%) and 47 women (54%) were included in this study. Median follow-up for patients was 98 months. Five-year recurrence-free and overall survival (OS) rates were 56% and 81%, respectively. Ki-67 and p53 expression was observed in 5 (6%) and 2 (2%) patients, respectively. αER and PR were all negative. The most important determinants of disease-free survival (DFS) were perineural invasion (PNI; p = .001) and female sex (p = .027). Disease site (major vs minor salivary gland) was the only predictor of worse OS on multivariate analysis.

CONCLUSION:

Perineural invasion, female sex, and disease site were the most consistent predictors of poor outcome in head and neck ACC.

© 2014 Wiley Periodicals, Inc.

KEYWORDS:

adenoid cystic carcinomas; disease-free survival; head and neck; overall survival; prognostic factors

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