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Psychogeriatrics. 2013 Dec;13(4):254-9. doi: 10.1111/psyg.12027. Epub 2013 Oct 24.

Three patients with mood disorders showing catatonia and frontotemporal lobes atrophy.

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  • 1Department of Psychiatry, Juntendo Koshigaya Hospital, Juntendo University School of Medicine, Saitama, Japan; Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.

Abstract

Here we report the cases of three patients with mood disorders showing catatonia and frontotemporal lobe atrophy. Catatonia is a syndrome linked to frontal dysfunction that most frequently occurs in patients with mood disorders. The diagnostic criteria of catatonia and frontotemporal dementia partly overlap. In the present patients, catatonia might be closely related to frontal dysfunction caused by frontotemporal lobe atrophy. With regard to therapeutics for catatonia, we found that administering a low dose of lorazepam alone or after electroconvulsive therapy may be useful for treating and preventing catatonia. We also found that administering glutaminate antagonists such as memantine may be useful for treating lorazepam-resistant catatonia.

© 2013 The Authors. Psychogeriatrics © 2013 Japanese Psychogeriatric Society.

KEYWORDS:

catatonia; electroconvulsive therapy; frontotemporal dementia; lorazepam; memantine mood disorder

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