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Respirology. 2013 Nov;18(8):1280-1. doi: 10.1111/resp.12197.

Exacerbation phenotyping in chronic obstructive pulmonary disease.

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  • 1Monash Lung and Sleep, Monash Medical Centre, Melbourne, Victoria, Australia.


Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are crucial events but causes remain poorly defined. A method to clinically 'phenotype' AECOPD have been proposed, and 52 hospitalized chronic obstructive pulmonary disease exacerbations according to underlying aetiology have now been prospectively phenotyped. Multiple exacerbation phenotypes were identified. A subpopulation coinfected with virus and bacteria had a significantly longer length of hospital stay, and this pilot study indicates that exacerbation phenotyping may be advantageous.

© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.


chronic obstructive pulmonary disease; clinical respiratory medicine; emphysema; infection and inflammation; viral infection

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