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Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13681-4. doi: 10.1002/anie.201305489. Epub 2013 Oct 23.

Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA.

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  • 1Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904 (Japan).


Cut loose: A pseudocomplementary peptide nucleic acid was tethered to a pyrrole/imidazole hairpin polyamide, and was used to selectively target a specific DNA sequence. Binding even occurs under high salt conditions. Furthermore, the conjugate facilitated sequence-specific scission of long dsDNA. This simple approach promises to resolve the technical difficulties in targeting DNA sequences with PNA.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


DNA cleavage; DNA recognition; amides; noncovalent interactions; peptide nucleic acids

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