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Cutis. 2013 Sep;92(3):148-50.

Methotrexate toxicity induced by ciprofloxacin leading to psoriatic plaque ulceration: a case report.

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  • 1515 Spruce St, San Francisco, CA 94118, USA.


We present the case of a 90-year-old woman with psoriasis vulgaris who had been treated with methotrexate for many years. The patient presented with psoriatic plaque ulcerations uniquely limited to the active border as well as acute oral ulcerations and severe gastrointestinal upset after undergoing a course of ciprofloxacin for treatment of a bacterial infection.

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