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Clin Neurophysiol. 2014 Apr;125(4):675-84. doi: 10.1016/j.clinph.2013.08.021. Epub 2013 Oct 17.

Electroencephalographic activity of preterm infants is increased by Family Nurture Intervention: a randomized controlled trial in the NICU.

Author information

  • 1Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Pathology & Cell Biology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address: mgw13@columbia.edu.
  • 2Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.
  • 3Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
  • 4Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
  • 5Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA; Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.
  • 6Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
  • 7Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

Abstract

OBJECTIVE:

To assess the impact of Family Nurture Intervention (FNI) on electroencephalogram (EEG) activity in preterm infants (26-34 weeks gestation).

METHODS:

Two groups were tested in a single, level IV neonatal intensive care unit (NICU; standard care or standard care plus FNI) using a randomized controlled trial design. The intervention consists of sessions designed to achieve mutual calm and promote communication of affect between infants and their mothers throughout the NICU stay. EEG recordings were obtained from 134 infants during sleep at ∼35 and ∼40 weeks postmenstrual age (PMA). Regional brain activity (power) was computed for 10 frequency bands between 1 and 48 Hz in each of 125 electrodes.

RESULTS:

Near to term age, compared to standard care infants, FNI infants showed robust increases in EEG power in the frontal polar region at frequencies 10 to 48 Hz (20% to 36% with p-values <0.0004). Effects were significant in both quiet and active sleep, regardless of gender, singleton-twin status, gestational age (26-30 or 30-35 weeks) or birth weight (<1500 or >1500 g).

CONCLUSION:

FNI leads to increased frontal brain activity during sleep, which other investigators find predictive of better neurobehavioral outcomes.

SIGNIFICANCE:

FNI may be a practicable means of improving outcomes in preterm infants.

Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Brain maturation; EEG; Maternal separation; Mother–infant intervention; Premature birth

[PubMed - indexed for MEDLINE]
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