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Enferm Infecc Microbiol Clin. 2014 May;32(5):280-4. doi: 10.1016/j.eimc.2013.07.012. Epub 2013 Oct 16.

Monitoring of children with acute gastroenteritis in Madrid, Spain, during 2010-2011: rotavirus genotype distribution after the vaccines introduction.

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  • 1Viral Gastroenteritis Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
  • 2Hospital Virgen del Rocío, Sevilla, Spain.
  • 3Viral Gastroenteritis Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
  • 4Hospital Severo Ochoa, Leganés, Madrid, Spain.



A structured surveillance study was conducted on children with diarrhea who were hospitalized in Madrid (Spain) during 2010-2011, in order to describe temporal, geographic, and age-related trends in rotavirus (RV) strains after the introduction of the RV vaccines in our country.


A total of 370 children were enrolled, with RV being detected in 117 (31.6%) cases. Coinfections were detected mainly with rotavirus, astrovirus and norovirus. The most prevalent rotavirus G type was G1 (60.7%) followed by G2 (16.09%), G9 (5.9%), and G12 (5.1%). The G12 genotype appeared for the first time in 2008 in Spain, and it has increased to 5.1% of the cases in this report. Some uncommon P genotypes, such as P[14] and P[6], both with a low percentage, were found. The samples with G1 G2, G9 and G12 genotypes appeared in all ages, but were significantly higher in children under 2 years old.


A long-term structured surveillance is required in the Spanish post vaccine era, in order to determine the prevalence and variability of RV genotypes. This will especially be needed to distinguish between changes occurring as a result of natural fluctuation in genotype or those (changes) that could be mediated by population immunity to the vaccines. In addition, it will be necessary to study the impact of the current vaccines on the circulating rotavirus strains and on the overall reduction in the prevalence of rotavirus disease among children in Spain.

Copyright © 2013 Elsevier España, S.L. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.


Diarrea; Diarrhea; Genotipos rotavirus; Rotavirus genotypes; Rotavirus vaccines; Vacuna rotavirus

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