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Oncol Lett. 2013 Oct;6(4):907-914. Epub 2013 Jul 22.

Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature.

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  • 1Department of Neurosurgery, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.


Studies of recurrent dysembryoplastic neuroepithelial tumors (DNTs) are distinctly rare. The present study reports the case of a 15-year-old female with a temporal lobe DNT, which recurred and transformed into an astrocytoma (WHO grade II) five years after an initial gross total resection (GTR). Furthermore, all the previous studies on recurrent DNT are reviewed. Although the majority of DNT cases demonstrate benign behavior, recurrent DNTs have been observed following a GTR of the tumor. Patients do not appear to benefit from post-operative adjuvant therapy, and inappropriate radiotherapy or chemotherapy may result in tumor recurrence or malignant transformation. The prognosis is favorable if a GTR of the recurrent tumor is achieved. The use of regular imaging examinations and the maintenance of a long-term follow-up is of importance following a tumor resection.


astrocytoma; dysembryoplastic neuroepithelial tumor; malignant transformation; prognosis; recurrent

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