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J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):934-44. doi: 10.1093/gerona/glt157. Epub 2013 Oct 17.

Comparative analysis of pancreatic changes in aged rats fed life long with sunflower, fish, or olive oils.

Author information

  • 1Bioengineering Institute, University Miguel Hernandez, Elche (Alicante), Spain.
  • 2Department of Pathology, Complejo Hospitalario de Jaén, Spain.
  • 3Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Physiology, University of Granada, Spain.
  • 4Department of Analytical Chemistry, Nutrition and Bromatology, University of Alicante, Spain.
  • 5Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
  • 6Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Biochemistry and Molecular Biology II, University of Granada, Spain.
  • 7Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Physiology, University of Granada, Spain. jlquiles@ugr.es.

Abstract

An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders. We aimed to study the effect of oil consumption on pancreas histology in order to find aging-related signs. To this end, three groups of rats were fed an isocaloric diet for 2 years, where virgin olive, sunflower, or fish oil was included. Pancreatic samples for microscopy and blood samples were collected at the moment of sacrifice. As a result, the sunflower oil-fed rats presented higher β-cell numbers and twice the insulin content than virgin olive oil-fed animals. In addition, rats fed with fish oil developed acinar fibrosis and macrophage infiltrates in peri-insular regions, compared with counterparts fed with virgin olive oil. Inflammation signs were less prominent in the sunflower group. The obtained data emphasize the importance of dietary fatty acids in determining pancreatic structure.

© The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

KEYWORDS:

Endocrine pancreas; Exocrine pancreas; Pancreatic aging; Pancreatic fibrosis of the elderly.; β-Cell

PMID:
24136874
[PubMed - indexed for MEDLINE]
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