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Wound Repair Regen. 2013 Nov-Dec;21(6):876-82. doi: 10.1111/wrr.12112. Epub 2013 Oct 17.

Antimicrobial effects of coprisin on wounds infected with Staphylococcus aureus in rats.

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  • 1Department of Pathology, College of Veterinary Medicine, Daegu, Gyenonggi-do, Republic of Korea.

Erratum in

  • Wound Repair Regen. 2014 Jan-Feb;22(1):142.

Abstract

Antimicrobial peptides (AMPs) are naturally produced antibiotics that play important roles in host defense mechanisms. These proteins are found in variety of animal and plant species. The antibiotic effects of AMPs are gaining attention for use in human medicine. In this study, the antimicrobial effects of coprisin, a novel AMP isolated from the dung beetle (Copris tripartitus), were evaluated. The peptide was used to treat rats with wounds infected with Staphylococcus aureus. Coprisin accelerated wound closure both grossly and microscopically compared with the untreated group. Additionally, treatment with this peptide decreased phosphorylated-Smad2/3 (p-Smad2/3) levels, a downstream factor of the transforming growth factor-β signaling pathway which is believed to inhibit reepithelization, in the nucleus and cytoplasm of regenerating cells. Moreover, increased cell populations and angiogenesis were observed in lesions treated with coprisin, suggesting that this peptide promotes wound healing via its antimicrobial activity against S. aureus. Our results demonstrated that coprisin is a potential therapeutic agent that can possibly replace traditional antibiotics and overcome microbial resistance.

© 2013 by the Wound Healing Society.

PMID:
24134388
[PubMed - indexed for MEDLINE]
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