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Sci Transl Med. 2013 Oct 16;5(207):207ps14. doi: 10.1126/scitranslmed.3006305.

Going with the flow: from circulating tumor cells to DNA.

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  • 1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.


Molecular analyses of circulating tumor DNA (ctDNA) in plasma from cancer patients have the potential to deliver minimally invasive diagnostic and disease-monitoring biomarkers. Drawing from experience gained through the translation of circulating tumor cell detection to clinical tests, we discuss ctDNA as a source of tumor material for biomarker development.

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