Mapping of type 1 poliovirus neutralization epitopes

Dev Biol Stand. 1985:60:337-42.

Abstract

Several independently variable neutralization epitopes were identified on type 1 poliovirus by testing various field isolates with a panel of homotypic monoclonal antibodies. According to their distribution among viruses tested, neutralization epitopes were classified as strain-specific or variable (V) and cross-reacting or constant (K). Operational, relationship between different neutralization epitopes was analysed by selecting mutants resistant to neutralization with monoclonal antibodies from wild Mahoney and attenuated Sabin type 1 poliovirus. The results of this study and their implication in the characterization of poliovirus antigenic structure by neutralization epitope formulae is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / immunology
  • Antibodies, Viral / immunology
  • Antigens, Viral / genetics*
  • Epitopes / genetics
  • Genes, Viral
  • Mutation
  • Neutralization Tests
  • Poliovirus / genetics
  • Poliovirus / immunology*
  • Poliovirus Vaccine, Inactivated / immunology
  • Poliovirus Vaccine, Oral / immunology

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Antigens, Viral
  • Epitopes
  • Poliovirus Vaccine, Inactivated
  • Poliovirus Vaccine, Oral