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J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):1259-61. doi: 10.1016/j.jstrokecerebrovasdis.2013.09.004. Epub 2013 Oct 12.

Lateral medullary stroke in patient with granulomatous polyangiitis.

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  • 1Department of Neurology, Albany Medical Center, Albany, New York. Electronic address:
  • 2Department of Neurology, Albany Medical Center, Albany, New York.
  • 3Department of Medicine, Division of Nephrology, Albany Medical Center, Albany, New York.
  • 4Department of Neurology, Albany Medical Center, Albany, New York; Department of Neurology and Neurosurgery, Albany Medical Center, Albany, New York.


Granulomatous polyangiitis (GPA), also known as Wegener granulomatosis, is a systemic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that infrequently affects the central nervous system. We report a 41-year-old man with lateral medullary infarction who developed rapidly progressive renal failure. He was diagnosed with GPA based on positive serum c-ANCA and antiproteinase 3 antibodies and demonstration of pauci-immune crescentic glomerulonephritis on kidney biopsy. He was treated with Coumadin, pulse steroids, cyclophosphamide, and plasmapheresis. He had resolution of his neurologic deficits and improvement in renal function. This case report highlights the importance to consider GPA vasculitis in the differential diagnosis of stroke in patients with development of acute kidney injury.

Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.


Stroke; Wegener granulomatosis; granulomatous polyangiitis; kidney injury; medulla oblongata

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