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Bioorg Med Chem Lett. 2013 Dec 1;23(23):6307-9. doi: 10.1016/j.bmcl.2013.09.063. Epub 2013 Oct 1.

Fluorescent conjugate of sLe(x)-selective bisboronic acid for imaging application.

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  • 1Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, PR China.


Carbohydrate-based biomarkers such as sialyl Lewis X are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed a boronolectin-fluorophore conjugate, which was able to selectively label and image xenograft (sc) tumor. This represents the very first example that a small molecule capable of recognizing a carbohydrate biomarker was used for optical imaging application.

Copyright © 2013 Elsevier Ltd. All rights reserved.


Biomarker; Boronolectin; Optical imaging; Xenograft tumer

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