Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Dig Liver Dis. 2014 Jan;46(1):67-71. doi: 10.1016/j.dld.2013.08.139. Epub 2013 Oct 12.

Defer or treat? Reasons for treatment decisions in patients with chronic hepatitis C genotype 1 in the early era of directly acting antiviral agents.

Author information

  • 11st Medical Department, Internal Medicine Department, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany. Electronic address: jens.kittner@unimedizin-mainz.de.
  • 21st Medical Department, Internal Medicine Department, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • 3Clinic of Psychosomatic Medicine and Psychotherapy, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Abstract

BACKGROUND:

In chronic genotype 1 hepatitis C, telaprevir or boceprevir plus peginterferon and ribavirin have become the new standard of care. Aim of this study was to identify factors contributing to the decision whether to defer or treat with the current triple regimens.

METHODS:

Prospective assessment of eight parameters on 0-4-point scales by the attending physician at a German tertiary referral centre between 1st September 2011 and 31st December 2012.

RESULTS:

307 patients were evaluated at least once by one of the 11 hepatologists involved; 267 patients were considered, but only 163 were recommended to receive triple therapy. Multivariate regression analysis revealed that a higher degree of fibrosis was most strongly associated with a recommendation for treatment (OR 2.69), followed by the patients' demand (OR 2.27), presumed efficacy (OR 1.62), and tolerability (OR 1.58). A high risk of decompensation was associated with the decision to defer (OR 0.39). Speed of progression, compliance, extrahepatic manifestation, gender and age were not significantly related to the recommendation. Treatment was finally started in 101 patients (32.9%).

CONCLUSION:

In chronic genotype 1 hepatitis C, advanced fibrosis and patients' preference are the main rationales to choose treatment rather than deferral in a real-life setting.

Copyright © 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

KEYWORDS:

Boceprevir; Chronic hepatitis C genotype 1; DAAs; Real-life data; Telaprevir; Therapy decision

PMID:
24125691
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk