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Nat Methods. 2013 Dec;10(12):1203-5. doi: 10.1038/nmeth.2682. Epub 2013 Oct 13.

Formation of targeted monovalent quantum dots by steric exclusion.

Author information

  • 11] Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA. [2] Tetrad Graduate Program, University of California San Francisco, San Francisco, California, USA. [3] Center for Systems and Synthetic Biology, University of California San Francisco, San Francisco, California, USA.

Abstract

Precise control over interfacial chemistry between nanoparticles and other materials remains a major challenge that limits broad application of nanotechnology in biology. To address this challenge, we used 'steric exclusion' to completely convert commercial quantum dots (QDs) into monovalent imaging probes by wrapping each QD with a functionalized oligonucleotide. We demonstrated the utility of these QDs as modular and nonperturbing imaging probes by tracking individual Notch receptors on live cells.

PMID:
24122039
[PubMed - indexed for MEDLINE]
PMCID:
PMC3968776
Free PMC Article

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