EZH2 takes the stage when BRCA1 loses

Cell Cycle. 2013 Dec 1;12(23):3575-6. doi: 10.4161/cc.26785. Epub 2013 Oct 11.
No abstract available

Keywords: BRCA1; EZH2; HOTAIR; PRC2; basal-like breast cancer; cancer therapy; embryonic stem cell; epigenetics; gene silencing; non-coding RNA.

Publication types

  • Editorial

MeSH terms

  • BRCA1 Protein / metabolism*
  • Enhancer of Zeste Homolog 2 Protein
  • Epithelial Cells / cytology
  • Epithelial Cells / metabolism
  • Female
  • Humans
  • Mammary Glands, Human / cytology
  • Polycomb Repressive Complex 2 / chemistry
  • Polycomb Repressive Complex 2 / metabolism*
  • RNA, Long Noncoding / metabolism

Substances

  • BRCA1 Protein
  • HOTAIR long untranslated RNA, human
  • RNA, Long Noncoding
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2