Send to:

Choose Destination
See comment in PubMed Commons below
Brain Behav Immun. 2014 Jul;39:211-9. doi: 10.1016/j.bbi.2013.10.002. Epub 2013 Oct 10.

High dietary protein restores overreaching induced impairments in leukocyte trafficking and reduces the incidence of upper respiratory tract infection in elite cyclists.

Author information

  • 1Health and Exercise Sciences Research Group, University of Stirling, Stirling FK9 4LA, Scotland, UK. Electronic address:
  • 2Department for Health, University of Bath, Bath BA2 7AY, UK.
  • 3Sport & Health Sciences, College of Life and Environmental Sciences, St. Luke's Campus, University of Exeter, Exeter EX1 2LU, Devon, UK.
  • 4DSM Biotechnology Center, Delft, The Netherlands.
  • 5Gatorade Sports Science Institute, Chicago, USA.
  • 6Department of Psychology, University of Amsterdam, The Netherlands; Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), Mannheim Medical Faculty, University of Heidelberg, Germany.
  • 7Health and Exercise Sciences Research Group, University of Stirling, Stirling FK9 4LA, Scotland, UK.


The present study examined whether a high protein diet prevents the impaired leukocyte redistribution in response to acute exercise caused by a large volume of high-intensity exercise training. Eight cyclists (VO2max: 64.2±6.5mLkg(-1)min(-1)) undertook two separate weeks of high-intensity training while consuming either a high protein diet (3gkg(-1)proteinBM(-1)day(-1)) or an energy and carbohydrate-matched control diet (1.5gkg(-1)proteinBM(-1)day(-1)). High-intensity training weeks were preceded by a week of normal-intensity training under the control diet. Leukocyte and lymphocyte sub-population responses to acute exercise were determined at the end of each training week. Self-reported symptoms of upper-respiratory tract infections (URTI) were monitored daily by questionnaire. Undertaking high-intensity training with a high protein diet restored leukocyte kinetics to similar levels observed during normal-intensity training: CD8(+) TL mobilization (normal-intensity: 29,319±13,130cells/μL×∼165min vs. high-intensity with protein: 26,031±17,474cells/μL×∼165min, P>0.05), CD8(+) TL egress (normal-intensity: 624±264cells/μL vs. high-intensity with protein: 597±478cells/μL, P>0.05). This pattern was driven by effector-memory populations mobilizing (normal-intensity: 6,145±6,227cells/μL×∼165min vs. high-intensity with protein: 6,783±8,203cells/μL×∼165min, P>0.05) and extravastating from blood (normal-intensity: 147±129cells/μL vs. high-intensity with protein: 165±192cells/μL, P>0.05). High-intensity training while consuming a high protein diet was associated with fewer symptoms of URTI compared to performing high-intensity training with a normal diet (P<0.05). To conclude, a high protein diet might reduce the incidence of URTI in athletes potentially mediated by preventing training-induced impairments in immune-surveillance.

Copyright © 2013 Elsevier Inc. All rights reserved.


CD8(+) T lymphocytes; Dietary protein; Immune-surveillance; Infection risk; Overtraining

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk