Send to:

Choose Destination
See comment in PubMed Commons below
Conf Proc IEEE Eng Med Biol Soc. 2013;2013:4118-20. doi: 10.1109/EMBC.2013.6610451.

Engineered virus-like nanoparticle heparin antagonists.


Virus nanoparticles provide a self-assembling, reproducible multivalent platform that can be chemically and genetically manipulated for the presentation of a wide array of epitopes. Presented herein are engineered bacteriophage Qβ nanoparticles that function as potent heparin antagonists. Three successful approaches have been used: 1) chemically appending poly-Arg peptides; 2) point mutations to Arg on the virus capsid; 3) incorporation of heparin-binding peptides displayed externally on the virus surface. Each approach generates particles with good heparin antagonist activity with none of the toxic side effects of protamine, the only drug currently FDA-approved for clinical use as a heparin antagonist.

[PubMed - in process]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IEEE Engineering in Medicine and Biology Society
    Loading ...
    Write to the Help Desk